Oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates & sulfonamide antibiotics may enhance the blood-glucose-lowering effect & increase susceptibility to hypoglycemia. Corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, estrogens & progestogens, phenothiazine derivatives, somatropin, sympathomimetic agents (eg, epinephrine adrenaline, salbutamol, terbutaline), & thyroid hormones may reduce blood glucose-lowering effect. β-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken blood-glucose-lowering effect. Pentamidine may cause hypoglycemia, which may be followed by hyperglycemia. Sympathomimetics eg, β-blockers, clonidine, guanethidine & reserpin may be reduced or absent the signs of adrenergic counter-regulation.
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